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Title: New Supramolecular Drug Carriers: The Study of Organogel Conjugated Gold Nanoparticles
Authors: Demchuk, Oleg M.
Kowalczuk, Joanna
Łapiński, Andrzej
Stolarczyk, Elżbieta
Kubiński, Konrad
Janeczko, Monika
Martyna, Aleksandra
Masłyk, Maciej
Turczyniak-Surdacka, Sylwia
Keywords: pharmaceutical gels; gold nanoparticles; SEM; Raman spectrometry; diffusiometry; TGA; biological activity
Issue Date: 2021
Publisher: MDPI
Citation: "Molecules", 2021, Vol. 26, nr 24, 7462
Abstract: An aqueous solution of sodium citrate stabilized gold nanoparticles (AuNP) in the presence of N-lauroyl-L-alanine (C12ALA) forms a stable gel. The structure of the gel and the distribution profile of AuNP in it were analyzed. Will nanoparticles separated from each other with sodium citrate behave in the same way in solution and trapped in the gel matrix? Will the spatial limitation of solvent molecules aggregate nanoparticles and destroy their homogeneity? These questions are very important from the point of view of the use of gold nanoparticles, trapped in the gel structure, as carriers of drugs in the slow-release process. The lack of homogeneity of this distribution will have a major impact on the rate of release of the appropriate amount of therapeutic drug from the matrix. In this work, we attempt to answer these questions. The performed biological assays revealed that both C12ALA and C12ALA-AuNP show an excellent level of biological neutrality. They might be used as a transporting medium for a drug delivery without affecting the drug’s activity.
DOI: 10.3390/molecules26247462
Appears in Collections:Artykuły naukowe (WNŚiNoZ)

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