New Supramolecular Drug Carriers: The Study of Organogel Conjugated Gold Nanoparticles

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dc.contributor.authorDemchuk, Oleg M.
dc.contributor.authorKowalczuk, Joanna
dc.contributor.authorŁapiński, Andrzej
dc.contributor.authorStolarczyk, Elżbieta
dc.contributor.authorKubiński, Konrad
dc.contributor.authorJaneczko, Monika
dc.contributor.authorMartyna, Aleksandra
dc.contributor.authorMasłyk, Maciej
dc.contributor.authorTurczyniak-Surdacka, Sylwia
dc.date.accessioned2022-06-23T09:50:17Z
dc.date.available2022-06-23T09:50:17Z
dc.date.issued2021
dc.description.abstractAn aqueous solution of sodium citrate stabilized gold nanoparticles (AuNP) in the presence of N-lauroyl-L-alanine (C12ALA) forms a stable gel. The structure of the gel and the distribution profile of AuNP in it were analyzed. Will nanoparticles separated from each other with sodium citrate behave in the same way in solution and trapped in the gel matrix? Will the spatial limitation of solvent molecules aggregate nanoparticles and destroy their homogeneity? These questions are very important from the point of view of the use of gold nanoparticles, trapped in the gel structure, as carriers of drugs in the slow-release process. The lack of homogeneity of this distribution will have a major impact on the rate of release of the appropriate amount of therapeutic drug from the matrix. In this work, we attempt to answer these questions. The performed biological assays revealed that both C12ALA and C12ALA-AuNP show an excellent level of biological neutrality. They might be used as a transporting medium for a drug delivery without affecting the drug’s activity.pl
dc.identifier.citation"Molecules", 2021, Vol. 26, nr 24, 7462pl
dc.identifier.doi10.3390/molecules26247462
dc.identifier.urihttp://hdl.handle.net/20.500.12153/3231
dc.language.isoenpl
dc.publisherMDPIpl
dc.rightsUznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pl/*
dc.subjectpharmaceutical gelspl
dc.subjectgold nanoparticlespl
dc.subjectSEMpl
dc.subjectRaman spectrometrypl
dc.subjectdiffusiometrypl
dc.subjectTGApl
dc.subjectbiological activitypl
dc.titleNew Supramolecular Drug Carriers: The Study of Organogel Conjugated Gold Nanoparticlespl
dc.typeinfo:eu-repo/semantics/articlepl
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