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dc.contributor.authorMasłyk, Maciej-
dc.contributor.authorJaneczko, Monika-
dc.contributor.authorMartyna, Aleksandra-
dc.contributor.authorCzernik, Sławomir-
dc.contributor.authorTokarska-Rodak, Małgorzata-
dc.contributor.authorChwedczuk, Marta-
dc.contributor.authorFoll-Josselin, Béatrice-
dc.contributor.authorRuchaud, Sandrine-
dc.contributor.authorBach, Stéphane-
dc.contributor.authorDemchuk, Oleg M.-
dc.contributor.authorKubiński, Konrad-
dc.identifier.citation"Molecules", 2019, Vol. 24, nr 1, 153pl
dc.description.abstractSmall molecules containing quinone and/or oxime moieties have been found as promising anti-fungal agents. One of them is 4-AN, a recently reported potent anti-Candida compound, which inhibits the formation of hyphae, decreases the level of cellular phosphoproteome, and finally shows no toxicity towards human erythrocytes and zebrafish embryos. Here, further research on 4-AN is presented. The results revealed that the compound: (i) Kills Candida clinical isolates, including these with developed antibiotic resistance, (ii) affects mature biofilm, and (iii) moderately disrupts membrane permeability. Atomic force microscopy studies revealed a slight influence of 4-AN on the cell surface architecture. 4-AN was also shown to inhibit multiple various protein kinases, a characteristic shared by most of the ATP-competitive inhibitors. The presented compound can be used in novel strategies in the fight against candidiasis, and reversible protein phosphorylation should be taken into consideration as a target in designing these
dc.rightsUznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska*
dc.subjectCandida albicanspl
dc.subjectprotein kinasespl
dc.subjectantifungal agentpl
dc.subjectatomic force microscopypl
dc.titleThe Anti-Candida albicans Agent 4-AN Inhibits Multiple Protein Kinasespl
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