The Anti-Candida albicans Agent 4-AN Inhibits Multiple Protein Kinases

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dc.contributor.authorMasłyk, Maciej
dc.contributor.authorJaneczko, Monika
dc.contributor.authorMartyna, Aleksandra
dc.contributor.authorCzernik, Sławomir
dc.contributor.authorTokarska-Rodak, Małgorzata
dc.contributor.authorChwedczuk, Marta
dc.contributor.authorFoll-Josselin, Béatrice
dc.contributor.authorRuchaud, Sandrine
dc.contributor.authorBach, Stéphane
dc.contributor.authorDemchuk, Oleg M.
dc.contributor.authorKubiński, Konrad
dc.date.accessioned2022-06-22T13:18:50Z
dc.date.available2022-06-22T13:18:50Z
dc.date.issued2019
dc.description.abstractSmall molecules containing quinone and/or oxime moieties have been found as promising anti-fungal agents. One of them is 4-AN, a recently reported potent anti-Candida compound, which inhibits the formation of hyphae, decreases the level of cellular phosphoproteome, and finally shows no toxicity towards human erythrocytes and zebrafish embryos. Here, further research on 4-AN is presented. The results revealed that the compound: (i) Kills Candida clinical isolates, including these with developed antibiotic resistance, (ii) affects mature biofilm, and (iii) moderately disrupts membrane permeability. Atomic force microscopy studies revealed a slight influence of 4-AN on the cell surface architecture. 4-AN was also shown to inhibit multiple various protein kinases, a characteristic shared by most of the ATP-competitive inhibitors. The presented compound can be used in novel strategies in the fight against candidiasis, and reversible protein phosphorylation should be taken into consideration as a target in designing these strategies.pl
dc.identifier.citation"Molecules", 2019, Vol. 24, nr 1, 153pl
dc.identifier.doi10.3390/molecules24010153
dc.identifier.urihttp://hdl.handle.net/20.500.12153/3224
dc.language.isoenpl
dc.publisherMDPIpl
dc.rightsUznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pl/*
dc.subjectCandida albicanspl
dc.subjectarylcyanomethylenequinonespl
dc.subject4-ANpl
dc.subjectprotein kinasespl
dc.subjectantifungal agentpl
dc.subjectatomic force microscopypl
dc.titleThe Anti-Candida albicans Agent 4-AN Inhibits Multiple Protein Kinasespl
dc.typeinfo:eu-repo/semantics/articlepl
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