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Title: The Anti-Candida albicans Agent 4-AN Inhibits Multiple Protein Kinases
Authors: Masłyk, Maciej
Janeczko, Monika
Martyna, Aleksandra
Czernik, Sławomir
Tokarska-Rodak, Małgorzata
Chwedczuk, Marta
Foll-Josselin, Béatrice
Ruchaud, Sandrine
Bach, Stéphane
Demchuk, Oleg M.
Kubiński, Konrad
Keywords: Candida albicans; arylcyanomethylenequinones; 4-AN; protein kinases; antifungal agent; atomic force microscopy
Issue Date: 2019
Publisher: MDPI
Citation: "Molecules", 2019, Vol. 24, nr 1, 153
Abstract: Small molecules containing quinone and/or oxime moieties have been found as promising anti-fungal agents. One of them is 4-AN, a recently reported potent anti-Candida compound, which inhibits the formation of hyphae, decreases the level of cellular phosphoproteome, and finally shows no toxicity towards human erythrocytes and zebrafish embryos. Here, further research on 4-AN is presented. The results revealed that the compound: (i) Kills Candida clinical isolates, including these with developed antibiotic resistance, (ii) affects mature biofilm, and (iii) moderately disrupts membrane permeability. Atomic force microscopy studies revealed a slight influence of 4-AN on the cell surface architecture. 4-AN was also shown to inhibit multiple various protein kinases, a characteristic shared by most of the ATP-competitive inhibitors. The presented compound can be used in novel strategies in the fight against candidiasis, and reversible protein phosphorylation should be taken into consideration as a target in designing these strategies.
DOI: 10.3390/molecules24010153
Appears in Collections:Artykuły naukowe (WNŚiNoZ)

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