|Title:||The Anti-Candida albicans Agent 4-AN Inhibits Multiple Protein Kinases|
Demchuk, Oleg M.
|Keywords:||Candida albicans; arylcyanomethylenequinones; 4-AN; protein kinases; antifungal agent; atomic force microscopy|
|Citation:||"Molecules", 2019, Vol. 24, nr 1, 153|
|Abstract:||Small molecules containing quinone and/or oxime moieties have been found as promising anti-fungal agents. One of them is 4-AN, a recently reported potent anti-Candida compound, which inhibits the formation of hyphae, decreases the level of cellular phosphoproteome, and finally shows no toxicity towards human erythrocytes and zebrafish embryos. Here, further research on 4-AN is presented. The results revealed that the compound: (i) Kills Candida clinical isolates, including these with developed antibiotic resistance, (ii) affects mature biofilm, and (iii) moderately disrupts membrane permeability. Atomic force microscopy studies revealed a slight influence of 4-AN on the cell surface architecture. 4-AN was also shown to inhibit multiple various protein kinases, a characteristic shared by most of the ATP-competitive inhibitors. The presented compound can be used in novel strategies in the fight against candidiasis, and reversible protein phosphorylation should be taken into consideration as a target in designing these strategies.|
|Appears in Collections:||Artykuły naukowe (WNŚiNoZ)|
|Maslyk_Janeczko_Martyna_Czernik_Tokarska-Rodak_Chwedczuk_Foll-Josselin_Ruchaud_Bach_Demchuk_Kubinski_The_Anti-Candida_albicans_Agent_4-AN.pdf||1.65 MB||Adobe PDF|
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