A General Phenomenon of Spontaneous Amplification of Optical Purity under Achiral Chromatographic Conditions

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dc.contributor.authorDemchuk, Oleg M.
dc.contributor.authorPietrusiewicz, Kazimierz Michał
dc.contributor.authorBorkowski, Mariusz
dc.contributor.authorStrzelecka, Dorota
dc.contributor.authorKielar, Katarzyna
dc.contributor.authorKicińska, Wioleta
dc.contributor.authorKarevych, Sergei
dc.contributor.authorJasiński, Radomir
dc.date.accessioned2022-06-22T13:13:20Z
dc.date.available2022-06-22T13:13:20Z
dc.date.issued2019
dc.description.abstractThis work explores the behavior of chiral compound mixtures enriched in one of the enantiomers whilst a typical chromatography on the achiral stationary phase is employed. The influence of several factors, such as the eluent composition, ratio of the compound to the stationary phase, and the initial enatiomeric purity of the compound used on the distribution of the enantiomers in the collected chromatographic fraction, was studied. The obtained results indicate that the phenomenon of Self Disproportionation of Enantiomer (SDE) occurred in all cases, and some of the collected fractions got higher optical purities than the initial one. Thus, achiral column chromatography could be applied in some cases as the simplest approach for chiral purification. Based on the experimental results and DFT calculations, an alternative concept explaining the SDE phenomenon was proposed. Due to its generality and simplicity, SDE may also be responsible for the formation of the first chiral non-racemic compounds on the early Earth.pl
dc.identifier.citation"Symmetry", 2019, Vol. 11, nr 5, 680pl
dc.identifier.doi10.3390/sym11050680
dc.identifier.urihttp://hdl.handle.net/20.500.12153/3221
dc.language.isoenpl
dc.publisherMDPIpl
dc.rightsUznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pl/*
dc.subjectenantiomer self-disproportionationpl
dc.subjectSDEpl
dc.subjectachiral stationary phasepl
dc.subjecthomochiral and heterochiral aggregatespl
dc.subjectchiral separationpl
dc.subjectchiralitypl
dc.subjectgenesis of life chiralitypl
dc.titleA General Phenomenon of Spontaneous Amplification of Optical Purity under Achiral Chromatographic Conditionspl
dc.typeinfo:eu-repo/semantics/articlepl
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