Novel functionalized β-nitrostyrenes: Promising candidates for new antibacterial drugs

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dc.contributor.authorDemchuk, Oleg M.
dc.contributor.authorBoguszewska-Czubara, Anna
dc.contributor.authorKula, Karolina
dc.contributor.authorWnorowski, Artur
dc.contributor.authorBiernasiuk, Anna
dc.contributor.authorPopiołek, Łukasz
dc.contributor.authorMiodowski, Dawid
dc.contributor.authorJasiński, Radomir
dc.date.accessioned2022-06-22T13:12:45Z
dc.date.available2022-06-22T13:12:45Z
dc.date.issued2019
dc.description.abstractThe process of searching for new antibacterial agents is more and more challenging due to the increasing drug resistance, which has become a major concern in the field of infection management. Our study presents a synthesis and characterization by IR, UV, 1H NMR and 13C NMR spectra of a homogenous series of 1-EWG functionalized 2-aryl-1-nitroethenes which could prove good candidates for the replacement of traditional antibacterial drugs In vitro screening against a panel of the reference strains of bacteria and fungi and their cytotoxicity towards cultured human HepG2 and HaCaT cells was performed. Antimicrobial results indicated that four of the synthesized compounds exhibited a significant antimicrobial activity against all tested reference bacteria and fungi belonging to yeasts with a specific and strong activity towards B. subtilis ATCC 6633. Two of these compounds had no detectable cytotoxicity towards the cultured human cell lines, making them promising candidates for new antibacterial drugs.pl
dc.identifier.citation"Saudi Pharmaceutical Journal", 2019, Vol. 27, nr 4, s. 593-601pl
dc.identifier.doi10.1016/j.jsps.2019.02.007
dc.identifier.issn1319-0164
dc.identifier.urihttp://hdl.handle.net/20.500.12153/3220
dc.language.isoenpl
dc.publisherElsevierpl
dc.rightsUznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pl/*
dc.subjectConjugated nitroalkenespl
dc.subjectAntimicrobial activitypl
dc.subjectFungicidal activitypl
dc.subjectCytotoxicitypl
dc.subjectB. subtilis ATCC 6633pl
dc.subjectHepG2 cellspl
dc.subjectHaCaT cellspl
dc.titleNovel functionalized β-nitrostyrenes: Promising candidates for new antibacterial drugspl
dc.typeinfo:eu-repo/semantics/articlepl
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