Role of Phytoestrogen-Rich Bioactive Substances (Linum usitatissimum L., Glycine max L., Trifolium pratense L.) in Cardiovascular Disease Prevention in Postmenopausal Women: A Systematic Review and Meta-Analysis

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dc.contributor.authorJach, Monika Elżbieta
dc.contributor.authorBłaszczuk, Agata
dc.contributor.authorBaranska, Agnieszka
dc.contributor.authorKanadys, Wiesław
dc.contributor.authorMalm, Maria
dc.contributor.authorReligioni, Urszula
dc.contributor.authorWróbel, Rafał
dc.contributor.authorHerda, Jolanta
dc.contributor.authorPolz-Dacewicz, Małgorzata
dc.date.accessioned2022-09-15T09:31:02Z
dc.date.available2022-09-15T09:31:02Z
dc.date.issued2022
dc.description.abstractThe aim of this report was to determine the impact of flaxseed, soy and red clover, and their bioactive substances on the lipid profile in postmenopausal women in cardiovascular diseases prevention. We used the following databases: MEDLINE (PubMed), EMBASE and the Cochrane Library. Meta-analysis indicates that the intake of flaxseed by postmenopausal women is associated with a statistically significant reduction in total cholesterol (TC) levels (weighted-mean difference (WMD) = −0.26; 95% confidence interval (95% CI): −0.38 to −0.13; p = 0.0001), low-density lipoprotein cholesterol (LDL-C) levels (WMD = −0.19; 95% CI: −0.30 to −0.08; p = 0.0006), and high-density lipoprotein cholesterol (HDL-C) levels (WMD = −0.06; 95% CI: −0.11 to −0.01; p = 0.0150). The effect of soy protein on the lipid profile showed a significant decrease in TC levels: WMD = −0.15; 95% CI: −0.25–0.05; p = 0.0048, LDL-C levels: WMD = −0.15; 95% CI: −0.25–0.05; p = 0.0067, as well as a significant increase in HDL-C levels: WMD = 0.05; 95% CI: 0.02–0.08; p = 0.0034. Changes in the lipid profile showed a significant reduction in TC levels after the use of red clover (WMD = −0.11; 95% CI: −0.18–−0.04; p = 0.0017) and a significant increase in HDL-C levels (WMD = 0.04; 95% CI: 0.01 to 0.07; p = 0.0165). This meta-analysis provides evidence that consuming flaxseed, soy and red clover can have a beneficial effect on lipids in postmenopausal women and suggest a favorable effect in preventing cardiovascular diseases.pl
dc.identifier.citation"Nutrients", 2022, Vol. 14, nr 12, 2467pl
dc.identifier.doi10.3390/nu14122467
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/20.500.12153/3557
dc.language.isoenpl
dc.publisherMDPIpl
dc.rightsUznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pl/*
dc.subjectflaxseedpl
dc.subjectsoypl
dc.subjectred cloverpl
dc.subjectlipid profilepl
dc.subjectmeta-analysispl
dc.subjectcardiovascular diseasepl
dc.subjectbotanical supplementspl
dc.subjectpostmenopausal womanpl
dc.titleRole of Phytoestrogen-Rich Bioactive Substances (Linum usitatissimum L., Glycine max L., Trifolium pratense L.) in Cardiovascular Disease Prevention in Postmenopausal Women: A Systematic Review and Meta-Analysispl
dc.typeinfo:eu-repo/semantics/articlepl
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