Mechanisms involved in the development of the small intestine mucosal layer in postnatal piglets

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dc.contributor.authorSkrzypek, Tomasz
dc.contributor.authorKazimierczak, Waldemar
dc.contributor.authorSkrzypek, Henryk
dc.contributor.authorValverde Piedra, Jose Luis
dc.contributor.authorGodlewski, Michał
dc.contributor.authorZabielski, Romuald
dc.date.accessioned2022-03-23T10:53:12Z
dc.date.available2022-03-23T10:53:12Z
dc.date.issued2018
dc.description.abstractThe use of complementary visualization and measurement techniques allowed accurate description and quantification of changes in the intestinal mucosal architecture and provided a comprehensive outlook on the dynamics of remodeling and maturation processes of the mucosal layer taking place in the small intestine of piglets from birth to weaning. The aim of the study was to examine the early postnatal development of the small intestine in pigs. Three techniques were used: scanning electron microscopy (measurements ofvillus density and shape, height ofenterocytes and microvilli, cell exfoliation, and location of extrusion zones), optical microscopy (cross section, measurement of structures: villus length and width; crypt depth; mucosal thickness), and confocal microscopy (cell localization, apoptosis, exfoliation and migration). The postnatal development ofthe mucosal layer ofthe small intestine was reflected in changes in the density, length, width, and shape of villi, crypt depth, replacement of enterocyte population, and arrangement. The presence of deep transverse furrows on villus corpus and vacuolated fetal-type enterocytes in the mucosal layer of the small intestine, which are able to engulf large amounts of colostrum shortly after birth, appears to play an important role in the observed phenomenon of straightening of the villus height and increasing of the villus diameter shortly after birth. We hypothesized that the intestinal mucosal layer is compressed before birth and ready to unfold within a short time after birth.pl
dc.identifier.citation"Journal of Physiology and Pharmacology", 2018, Vol. 69, nr 1, s. 127-138pl
dc.identifier.doi10.26402/jpp.2018.1.14
dc.identifier.issn0867-5910
dc.identifier.urihttp://hdl.handle.net/20.500.12153/2854
dc.language.isoenpl
dc.publisherKraków: Polish Physiological Societypl
dc.subjectdevelopment of the small intestinepl
dc.subjectscanning electron microscopypl
dc.subjectvillipl
dc.subjectenterocytespl
dc.subjectapoptosispl
dc.subjectextrusion zonespl
dc.subjectmaturationpl
dc.subjectconfocal microscopypl
dc.titleMechanisms involved in the development of the small intestine mucosal layer in postnatal pigletspl
dc.typeinfo:eu-repo/semantics/articlepl
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