Cholinesterase inhibitors isolated from bilberry fruit

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dc.contributor.authorDemchuk, Oleg M.
dc.contributor.authorBorowiec, Kamila
dc.contributor.authorSzwajgier, Dominik
dc.contributor.authorTargoński, Zdzisław
dc.contributor.authorCybulska, Justyna
dc.contributor.authorCzernecki, Tomasz
dc.contributor.authorMalik, Agnieszka
dc.date.accessioned2022-08-05T09:37:44Z
dc.date.available2022-08-05T09:37:44Z
dc.date.issued2014
dc.description.abstractCholinesterases (ChEs) are key enzymes in the pathogenesis of Alzheimer's disease (AD). A growing body of evidence suggests that plants deliver compounds able to inhibit ChEs (e.g., huperzine A, galanthamine, and physostigmine), thus playing a beneficial therapeutic role in the treatment of AD. Screening for cholinesterase inhibitors (ChEIs) in selected fruits and vegetables showed that extract prepared from bilberry fruit effectively inhibited the activity of acetyl- and butyrylcholinesterase. The purification of ChEIs from bilberry fruit followed by HPLC-UV, FT-IR, NMR, and LC–MS demonstrated that the studied compounds were derivatives of chlorogenic and benzoic acids. These results confirm that bilberry fruit may serve as a useful source of ChEIs, leading to the attenuation of memory deficit caused by AD.pl
dc.identifier.citation"Journal of Functional Foods", 2014, Vol. 11, s. 313-321pl
dc.identifier.doi10.1016/j.jff.2014.10.008
dc.identifier.issn1756-4646
dc.identifier.urihttp://hdl.handle.net/20.500.12153/3430
dc.language.isoenpl
dc.publisherElsevierpl
dc.rightsUznanie autorstwa 3.0 Polska*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/pl/*
dc.subjectBilberrypl
dc.subjectAcetylcholinesterasepl
dc.subjectButyrylcholinesterasepl
dc.subjectInhibitorpl
dc.subjectAlzheimer's diseasepl
dc.titleCholinesterase inhibitors isolated from bilberry fruitpl
dc.typeinfo:eu-repo/semantics/articlepl
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