Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12153/3232
Title: A representative of arylcyanomethylenequinone oximes effectively inhibits growth and formation of hyphae in Candida albicans and influences the activity of protein kinases in vitro
Authors: Masłyk, Maciej
Janeczko, Monika
Demchuk, Oleg M.
Boguszewska-Czubara, Anna
Golczyk, Hieronim
Sierosławska, Anna
Rymuszka, Anna
Martyna, Aleksandra
Kubiński, Konrad
Keywords: Arylcyanomethylenequinone oximes; Antifungal agents; Candida albicans; Hyphae; Phosphorylation
Issue Date: 2018
Publisher: Elsevier
Citation: "Saudi Pharmaceutical Journal", 2018, Vol. 26, nr 2, s. 244-252
Abstract: In this study, we applied various assays to reveal new activities of phenylcyanomethylenequinone oxime-4-(hydroxyimino) cyclohexa-2,5-dien-1-ylidene](phenyl)ethanenitrile (4-AN) for potential anti-microbial applications. These assays demonstrated (a) the antimicrobial effect on bacterial and fungal cultures, (b) the effect on the in vitro activity of the kinase CK2, (c) toxicity towards human erythrocytes, the Caco-2 cancer cell line, and embryonic development of Zebrafish. We demonstrated the activity of 4-AN against selected bacteria and Candida spp. The MIC ranging from 4 µg/ml to 125 µg/ml proved effective in inhibition of formation of hyphae and cell aggregation in Candida, which was demonstrated at the cytological level. Noteworthy, 4-AN was found to inhibit the CK2 kinase with moderate potency. Moreover, at low concentrations, it did not exert any evident toxic effects on human erythrocytes, Caco-2 cells, or Zebrafish embryos. 4-AN can be a potential candidate as a novel drug against Candida infections.
URI: http://hdl.handle.net/20.500.12153/3232
DOI: 10.1016/j.jsps.2017.12.004
Appears in Collections:Artykuły naukowe (WNŚiNoZ)

Files in This Item:
File Description SizeFormat 
Maslyk_Janeczko_Demchuk_Boguszewska-Czubara_Golczyk_Sieroslawska_Rymuszka_Martyna_Kubinski_A_representative_of_arylcyanomethylenequinone_oximes.pdf1.33 MBAdobe PDFThumbnail
View/Open
Show full item record



This item is licensed under a Creative Commons License Creative Commons