Browsing by Author "Kula, Karolina"

Now showing 1 - 2 of 2
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    A clean and simple method for deprotection of phosphines from borane complexes
    (Walter de Gruyter, 2017) Demchuk, Oleg M.; Jasiński, Radomir; Strzelecka, Dorota; Dziuba, Kamil; Kula, Karolina; Chrzanowski, Jacek; Krasowska, Dorota
    Simple, efficient, clean, and stereospecific protocols of protection of phosphorus atom with borane and deprotection from the borane complexes of the tertiary phosphines in mild conditions are reported. The proposed protection/deprotection reactions tolerate a range of functional groups and lead to pure products with excellent yield with no need for application of chromatographic or crystallisation purification procedures. For the first time mechanisms of the reactions of phosphine protection and deprotection have been studied based on experimental kinetic data as well as quantumchemical calculations, which allows designing reaction conditions suitable for a given substrate.
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    Novel functionalized β-nitrostyrenes: Promising candidates for new antibacterial drugs
    (Elsevier, 2019) Demchuk, Oleg M.; Boguszewska-Czubara, Anna; Kula, Karolina; Wnorowski, Artur; Biernasiuk, Anna; Popiołek, Łukasz; Miodowski, Dawid; Jasiński, Radomir
    The process of searching for new antibacterial agents is more and more challenging due to the increasing drug resistance, which has become a major concern in the field of infection management. Our study presents a synthesis and characterization by IR, UV, 1H NMR and 13C NMR spectra of a homogenous series of 1-EWG functionalized 2-aryl-1-nitroethenes which could prove good candidates for the replacement of traditional antibacterial drugs In vitro screening against a panel of the reference strains of bacteria and fungi and their cytotoxicity towards cultured human HepG2 and HaCaT cells was performed. Antimicrobial results indicated that four of the synthesized compounds exhibited a significant antimicrobial activity against all tested reference bacteria and fungi belonging to yeasts with a specific and strong activity towards B. subtilis ATCC 6633. Two of these compounds had no detectable cytotoxicity towards the cultured human cell lines, making them promising candidates for new antibacterial drugs.